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A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model
Chaperonins mediate protein folding in a cavity formed by multisubunit rings. The human CCT has eight non-identical subunits and the His147Arg mutation in one subunit, CCT5, causes neuropathy. Knowledge is scarce on the impact of this and other mutations upon the chaperone's structure and funct...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4209464/ https://ncbi.nlm.nih.gov/pubmed/25345891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06688 |
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