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Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F Na(V)1.7 sodium channels
BACKGROUND AND PURPOSE: The non-selective sodium channel inhibitor mexiletine has been found to be effective in several animal models of chronic pain and has become popular in the clinical setting as an orally available alternative to lidocaine. It remains unclear why patients with monogenic pain di...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4209151/ https://ncbi.nlm.nih.gov/pubmed/24866741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12788 |
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