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ALK in Lung Cancer: Past, Present, and Future

In 2007, scientists discovered that anaplastic lymphoma kinase (ALK) gene rearrangements are present in a small subset of non–small-cell lung cancers. ALK-positive cancers are highly sensitive to small-molecule ALK kinase inhibitors, such as crizotinib. Phase I and II studies of crizotinib in ALK-po...

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Detalhes bibliográficos
Main Authors: Shaw, Alice T., Engelman, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209068/
https://ncbi.nlm.nih.gov/pubmed/23401436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.44.5353
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