Silibinin Prevents Prostate Cancer Cell-Mediated Differentiation of Naïve Fibroblasts into Cancer-Associated Fibroblast Phenotype by Targeting TGF β2

Tumor microenvironment is an essential element in prostate cancer (PCA), offering unique opportunities for its prevention. Tumor microenvironment includes naïve fibroblasts that are recruited by nascent neoplastic lesion and altered into ‘cancer-associated fibroblasts’ (CAFs) that promote PCA. A bet...

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Detalhes bibliográficos
Main Authors: Ting, Harold, Deep, Gagan, Jain, Anil K., Cimic, Adela, Sirintrapun, Joseph, Romero, Lina M., Cramer, Scott D., Agarwal, Chapla, Agarwal, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208986/
https://ncbi.nlm.nih.gov/pubmed/24615813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22135
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