MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors

BACKGROUND: Dietary restriction (DR) has been shown to prolong longevity across diverse taxa, yet the mechanistic relationship between DR and longevity remains unclear. MicroRNAs (miRNAs) control aging-related functions such as metabolism and lifespan through regulation of genes in insulin signaling...

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Hauptverfasser: Smith-Vikos, Thalyana, de Lencastre, Alexandre, Inukai, Sachi, Shlomchik, Mariel, Holtrup, Brandon, Slack, Frank J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208828/
https://ncbi.nlm.nih.gov/pubmed/25242029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.08.013
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