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Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation

Arsenite (As) causes transformation of human osteogenic sarcoma cells (HOS) when applied continuously at low doses (0.1–0.5 μM) during 8-weeks of exposure. However, the mechanisms by which As transforms human cells are not known. We investigated whether alterations occurred in gene expression and pr...

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Detalhes bibliográficos
Main Authors: Wu, Jing, Sowinska, Anna, Huang, Xi, Klein, Catherine B., Pelle, Edward, Frenkel, Krystyna
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208698/
https://ncbi.nlm.nih.gov/pubmed/22692362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10534-012-9559-1
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