Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion

We previously demonstrated that micro-RNAs (miRNAs) 132 and 212 are differentially upregulated in response to obesity in two mouse strains that differ in their susceptibility to obesity-induced diabetes. Here we show the overexpression of miRNAs 132 and 212 enhances insulin secretion (IS) in respons...

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Autors principals: Soni, Mufaddal S., Rabaglia, Mary E., Bhatnagar, Sushant, Shang, Jin, Ilkayeva, Olga, Mynatt, Randall, Zhou, Yun-Ping, Schadt, Eric E., Thornberry, Nancy A., Muoio, Deborah M., Keller, Mark P., Attie, Alan D.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207388/
https://ncbi.nlm.nih.gov/pubmed/24969106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1677
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