Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis

Parthenolide, a natural product derived from Feverfew, prevents septic shock and inflammation. We aimed to identify the effects of parthenolide on the RANKL (receptor activator of NF-κB ligand)-induced differentiation and bone resorbing activity of osteoclasts. In this study, parthenolide dose-depen...

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Autores principales: Kim, Ju-Young, Cheon, Yoon-Hee, Yoon, Kwon-Ha, Lee, Myeung Su, Oh, Jaemin
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206717/
https://ncbi.nlm.nih.gov/pubmed/24314143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2014.47.8.206
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