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mTORC1 Signaling in Oocytes Is Dispensable for the Survival of Primordial Follicles and for Female Fertility

The molecular mechanisms underlying reproductive aging and menopausal age in female mammals are poorly understood. Mechanistic target of rapamycin complex 1 (mTORC1) is a central controller of cell growth and proliferation. To determine whether mTORC1 signaling in oocytes plays a direct role in phys...

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Autors principals: Gorre, Nagaraju, Adhikari, Deepak, Lindkvist, Rebecca, Brännström, Mats, Liu, Kui, Shen, Yan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206408/
https://ncbi.nlm.nih.gov/pubmed/25338086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110491
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