Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering

ABL1 tyrosine-kinase inhibitors (TKI) are a front-line therapy for chronic myelogenous leukemia and represent the best known examples of targeted cancer therapeutics. However, the dynamic uptake of low molecular weight TKIs into cells and their intracellular behavior is largely unknown due to the di...

Full description

Saved in:
Bibliographic Details
Main Authors: Fu, Dan, Zhou, Jing, Zhu, Wenjing Suzanne, Manley, Paul W., Wang, Y. Karen, Hood, Tami, Wylie, Andrew, Xie, X. Sunney
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205760/
https://ncbi.nlm.nih.gov/pubmed/24950332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1961
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items