Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations

Germ cells are maintained in a pristine non-aging state as they proliferate over generations. Here, we show that a novel function of the Caenorhabditis elegans RNA interference proteins RNAi spreading defective (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature. rsd mutants cu...

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Bibliografiske detaljer
Main Authors: Sakaguchi, Aisa, Sarkies, Peter, Simon, Matt, Doebley, Anna-Lisa, Goldstein, Leonard D., Hedges, Ashley, Ikegami, Kohta, Alvares, Stacy M., Yang, Liwei, LaRocque, Jeannine R., Hall, Julie, Miska, Eric A., Ahmed, Shawn
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205660/
https://ncbi.nlm.nih.gov/pubmed/25258416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406131111
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