Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA

An intravenous step-down infusion procedure that maintained a constant gadolinium-diethylene-triaminepentaacetic acid (Gd-DTPA) blood concentration and magnetic resonance imaging (MRI) were used to localize and quantify the blood–brain barrier (BBB) opening in a rat model of transient cerebral ische...

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Main Authors: Knight, Robert A, Karki, Kishor, Ewing, James R, Divine, George W, Fenstermacher, Joseph D, Patlak, Clifford S, Nagaraja, Tavarekere N
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205544/
https://ncbi.nlm.nih.gov/pubmed/19319145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.20
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