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Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or rapamycin

Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion junctions of these molecules are attractive candidates for molecularly targeted therapeutic intervention using R...

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Udgivet i:J Clin Invest
Principais autores: Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, Griffin, James D., Shi, Yang, Gilliland, D. Gary
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC420507/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15199413/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20673
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