Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate

Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process. Using Fgf10–/–, FGF receptor 2b–/– (Fgfr2b–/–), and Sonic hedgehog (Shh) mutant mice, which all exhibit cleft palate, we show...

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Main Authors: Rice, Ritva, Spencer-Dene, Bradley, Connor, Elaine C., Gritli-Linde, Amel, McMahon, Andrew P., Dickson, Clive, Thesleff, Irma, Rice, David P.C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420504/
https://ncbi.nlm.nih.gov/pubmed/15199404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420384
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