Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors

Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with deve...

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Autori principali: Koster, Roelof, Mitra, Nandita, D'Andrea, Kurt, Vardhanabhuti, Saran, Chung, Charles C., Wang, Zhaoming, Loren Erickson, R., Vaughn, David J., Litchfield, Kevin, Rahman, Nazneen, Greene, Mark H., McGlynn, Katherine A., Turnbull, Clare, Chanock, Stephen J., Nathanson, Katherine L., Kanetsky, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Association Studies Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204765/
https://ncbi.nlm.nih.gov/pubmed/24943593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu305
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