Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors

Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with deve...

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Hlavní autoři: Koster, Roelof, Mitra, Nandita, D'Andrea, Kurt, Vardhanabhuti, Saran, Chung, Charles C., Wang, Zhaoming, Loren Erickson, R., Vaughn, David J., Litchfield, Kevin, Rahman, Nazneen, Greene, Mark H., McGlynn, Katherine A., Turnbull, Clare, Chanock, Stephen J., Nathanson, Katherine L., Kanetsky, Peter A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204765/
https://ncbi.nlm.nih.gov/pubmed/24943593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu305
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