Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

N-Methyl-D-aspartate (NMDA, 200 microM) evokes the release of [3H]norepinephrine ([3H]NE) from preloaded hippocampal slices. This effect is potentiated by dehydroepiandrosterone sulfate (DHEA S), whereas it is inhibited by pregnenolone sulfate (PREG S) and the high-affinity sigma inverse agonist 1,3...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Monnet, F P, Mahé, V, Robel, P, Baulieu, E E
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42044/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3774
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