A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor.

The reduced progesterone metabolite tetrahydroprogesterone (3 alpha-hydroxy-5 alpha-pregnan-20-one; 3 alpha,5 alpha-THP) is a positive modulator of the gamma-aminobutyric acid type A (GABAA) receptor. Experiments performed in vitro with hypothalamic fragments have previously shown that GABA could mo...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	el-Etr, M, Akwa, Y, Fiddes, R J, Robel, P, Baulieu, E E
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1995
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3769
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