Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties

Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, namely statins, exert pleiotropic actions beyond lipid-lowering effects. Their pharmacological activity on atherosclerotic plaque stability and vascular inflammation appears to be mediated, at least in part, by nitric oxide (NO). With...

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Détails bibliographiques
Auteurs principaux: Ongini, Ennio, Impagnatiello, Francesco, Bonazzi, Albino, Guzzetta, Massimiliano, Govoni, Mirco, Monopoli, Angela, Del Soldato, Piero, Ignarro, Louis J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC420422/
https://ncbi.nlm.nih.gov/pubmed/15173604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401996101
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