3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex

FK506-binding protein 52 (FKBP52), which binds FK506 and possesses peptidylprolyl isomerase activity, is an important immunophilin involved in the heterocomplex of steroid receptors with heat-shock protein 90. Here we report the crystal structures of two overlapped fragments [N(1–260) and C(145–459)...

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Detalhes bibliográficos
Main Authors: Wu, Beili, Li, Pengyun, Liu, Yiwei, Lou, Zhiyong, Ding, Yi, Shu, Cuiling, Ye, Sheng, Bartlam, Mark, Shen, Beifen, Rao, Zihe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC420397/
https://ncbi.nlm.nih.gov/pubmed/15159550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305969101
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