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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F
The majority of patients with myeloproliferative neoplasms (MPNs) carry a somatic JAK2-V617F mutation. Because additional mutations can precede JAK2-V617F, it is questioned whether JAK2-V617F alone can initiate MPN. Several mouse models have demonstrated that JAK2-V617F can cause MPN; however, in al...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4203945/ https://ncbi.nlm.nih.gov/pubmed/25288396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131371 |
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