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Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

Rhabdomyosarcoma is the most frequent soft tissue sarcoma in children and adolescents, with a high rate of relapse that dramatically affects the clinical outcome. Multiagent chemotherapy, in combination with surgery and/or radiation therapy, is the treatment of choice. However, the relapse rate is d...

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Autori principali: Salerno, Manuela, Avnet, Sofia, Bonuccelli, Gloria, Hosogi, Shigekuni, Granchi, Donatella, Baldini, Nicola
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203792/
https://ncbi.nlm.nih.gov/pubmed/25329465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110340
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