Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

Transition metal copper (Cu) can exist in oxidized or reduced states in cells, leading to cytotoxicity in cancer cells through oxidative stress. Recently, copper complexes are emerging as a new class of anticancer compounds. Here, we report that a novel anticancer copper complex (HYF127c/Cu) induces...

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Detalles Bibliográficos
Autores principales: Zhong, Wu, Zhu, Haichuan, Sheng, Fugeng, Tian, Yonglu, Zhou, Jun, Chen, Yingyu, Li, Song, Lin, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2014
Materias:
Translational Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203553/
https://ncbi.nlm.nih.gov/pubmed/24905917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28789
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