Combined autophagy and HDAC inhibition: A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

We previously reported that inhibition of autophagy significantly augmented the anticancer activity of the histone deacetylase (HDAC) inhibitor vorinostat (VOR) through a cathepsin D-mediated mechanism. We thus conducted a first-in-human study to investigate the safety, preliminary efficacy, pharmac...

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Detalhes bibliográficos
Main Authors: Mahalingam, Devalingam, Mita, Monica, Sarantopoulos, John, Wood, Leslie, Amaravadi, Ravi K, Davis, Lisa E, Mita, Alain C, Curiel, Tyler J, Espitia, Claudia M, Nawrocki, Steffan T, Giles, Francis J, Carew, Jennifer S
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203517/
https://ncbi.nlm.nih.gov/pubmed/24991835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29231
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