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Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.

We have prepared a family of peptide fragments of the 64-residue chymotrypsin inhibitor 2, corresponding to its progressive elongation from the N terminus. The growing polypeptide chain has little tendency to form stable structure until it is largely synthesized, and what structures are formed are n...

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Detalhes bibliográficos
Main Authors: De Prat Gay, G, Ruiz-Sanz, J, Neira, J L, Itzhaki, L S, Fersht, A R
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42025/
https://ncbi.nlm.nih.gov/pubmed/7731965
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