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SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation

Melanoma causes more deaths than any other skin cancer, and its incidence in the US continues to rise. Current medical therapies are insufficient to control this deadly neoplasm, necessitating the development of new target-based approaches. The objective of this study was to determine the role and f...

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Autors principals: Wilking, Melissa J., Singh, Chandra K., Nihal, Minakshi, Zhong, Weixiong, Ahmad, Nihal
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201895/
https://ncbi.nlm.nih.gov/pubmed/24751483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.04.001
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