Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM Assay

This work describes the coupling of the IR-MALDESI imaging source with the Q Exactive mass spectrometer. IR-MALDESI MSI was used to elucidate the spatial distribution of several HIV drugs in cervical tissues that had been incubated in either a low or high concentration. Serial sections to those anal...

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Bibliographic Details
Main Authors: Barry, Jeremy A., Robichaud, Guillaume, Bokhart, Mark T., Thompson, Corbin, Sykes, Craig, Kashuba, Angela D.M., Muddiman, David C.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201889/
https://ncbi.nlm.nih.gov/pubmed/24744212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-014-0884-1
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