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IGF-2 is necessary for Retinoblastoma-mediated enhanced adaptation after small bowel resection

BACKGROUND: Previously, we have demonstrated that genetically disrupting retinoblastoma protein (Rb) expression in enterocytes results in taller villi, mimicking resection-induced adaption responses. Rb deficiency also results in elevated IGF-2 expression in villus enterocytes. We propose that posto...

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Autores principales: Choi, Pamela M., Sun, Raphael C., Sommovilla, Josh, Diaz-Miron, Jose, Guo, Jun, Erwin, Christopher R., Warner, Brad W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201888/
https://ncbi.nlm.nih.gov/pubmed/25002022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11605-014-2586-1
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