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Endogenous kisspeptin tone is a critical excitatory component of spontaneous GnRH activity and the GnRH response to NPY and CART

BACKGROUND/AIMS: Kisspeptin is the major excitatory regulator of GnRH neurons and is responsible for basal GnRH/LH release and the GnRH/LH surge. Although it is widely assumed, based on mutations in kisspeptin and Kiss1R, that kisspeptin acts to sustain basal GnRH neuronal activity, there have been...

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Hlavní autoři: Verma, Saurabh, Kirigiti, Melissa, Millar, Robert P., Grove, Kevin L., Smith, M. Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201869/
https://ncbi.nlm.nih.gov/pubmed/25011649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000365419
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