A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation

HIV-1 Tat stimulates transcription elongation by recruiting the P-TEFb (positive transcription elongation factor-b) (CycT1:CDK9) C-terminal domain (CTD) kinase to the HIV-1 promoter. Here we show that Tat transactivation also requires the Ssu72 CTD Ser5P (S5P)-specific phosphatase, which mediates tr...

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Detalhes bibliográficos
Main Authors: Chen, Yupeng, Zhang, Lirong, Estarás, Conchi, Choi, Seung H., Moreno, Luis, Karn, Jonathan, Moresco, James J., Yates, John R., Jones, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201287/
https://ncbi.nlm.nih.gov/pubmed/25319827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.250449.114
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