Caspase-dependent Regulation of Histone Deacetylase 4 Nuclear-Cytoplasmic Shuttling Promotes Apoptosis

Histone deacetylases (HDACs) are important regulators of gene expression as part of transcriptional corepressor complexes. Here, we demonstrate that caspases can repress the activity of the myocyte enhancer factor (MEF)2C transcription factor by regulating HDAC4 processing. Cleavage of HDAC4 occurs...

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Bibliografiske detaljer
Main Authors: Paroni, Gabriela, Mizzau, Michela, Henderson, Clare, Del Sal, Giannino, Schneider, Claudio, Brancolini, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2004
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420104/
https://ncbi.nlm.nih.gov/pubmed/15075374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-08-0624
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