OP35 THE PPARγ AGONIST PIOGLITAZONE UPREGULATES EAAT2 EXPRESSION IN HUMAN GLIOBLASTOMA CELLS

INTRODUCTION: Glioblastoma multiforme (GBM) cells release glutamate through expression of system x(c)(−), which exchanges intracellular glutamate for extracellular cysteine. Lack of glutamate uptake through low excitatory amino acid transporter 2 (EAAT2) expression permits high extracellular glutama...

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Auteurs principaux: Ching, Jared, Amiridis, Stephanie, Bjorksten, Andrew, Zheng, Thomas, Stylli, Stanley, Morokoff, Andrew, O'Brien, Terence, Kaye, Andrew H.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200979/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou251.33
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