CES2, ABCG2, TS and Topo-I Primary and Synchronous Metastasis Expression and Clinical Outcome in Metastatic Colorectal Cancer Patients Treated with First-Line FOLFIRI Regimen

Enzymatic activation of irinotecan (CPT-11) is due to carboxylesterase (CES), and its pharmacological behavior is influenced by drug resistance-related proteins. We previously reported that the clinical response and prognosis of metastatic colorectal cancer (mCRC) patients did not differ in tumors w...

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Main Authors: Silvestris, Nicola, Simone, Giovanni, Partipilo, Giulia, Scarpi, Emanuela, Lorusso, Vito, Brunetti, Anna Elisabetta, Maiello, Evaristo, Paradiso, Angelo, Mangia, Anita
Format: Artigo
Language:Inglês
Published: MDPI 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200864/
https://ncbi.nlm.nih.gov/pubmed/25198900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms150915767
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