Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes

Expression of the pro-angiogenic vascular endothelial growth factor (VEGF) stimulates angiogenesis and correlates with the progression of osteoarthritis. Mechanical joint loading seems to contribute to this cartilage pathology. Cyclic equibiaxial strains of 1% to 16% for 12 h, respectively, induced...

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Main Authors: Beckmann, Rainer, Houben, Astrid, Tohidnezhad, Mersedeh, Kweider, Nisreen, Fragoulis, Athanassios, Wruck, Christoph J., Brandenburg, Lars O., Hermanns-Sachweh, Benita, Goldring, Mary B., Pufe, Thomas, Jahr, Holger
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200847/
https://ncbi.nlm.nih.gov/pubmed/25257525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms150915456
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