A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance and a postulated role in different neuropsychiatric disorders, such as drug addiction, depression, and schizophrenia, there is a need for pharmacological tools that selectively target such receptor complexes in order...

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Bibliographic Details
Main Authors: Hasbi, Ahmed, Perreault, Melissa L., Shen, Maurice Y. F., Zhang, Lucia, To, Ryan, Fan, Theresa, Nguyen, Tuan, Ji, Xiaodong, O'Dowd, Brian F., George, Susan R.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2014
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200327/
https://ncbi.nlm.nih.gov/pubmed/25063849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-254037
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