Mammalian Mitochondrial and Cytosolic Folylpolyglutamate Synthetase Maintain the Subcellular Compartmentalization of Folates

Folylpoly-γ-glutamate synthetase (FPGS) catalyze the addition of multiple glutamates to tetrahydrofolate derivatives. Two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria in mouse and human tissues. We sought to clarify the functions of these two compartmentalized i...

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Detalhes bibliográficos
Main Authors: Lawrence, Scott A., Titus, Steven A., Ferguson, Jennifer, Heineman, Amy L., Taylor, Shirley M., Moran, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200287/
https://ncbi.nlm.nih.gov/pubmed/25164808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593244
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