Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis

IFNβ is a common therapeutic option to treat multiple sclerosis. It is unique among the family of type I IFNs in that it binds to the interferon receptors with high affinity, conferring exceptional biological properties. We have previously reported the generation of an interferon superagonist (dubbe...

Full description

Saved in:
Bibliographic Details
Main Authors: Harari, Daniel, Kuhn, Nadine, Abramovich, Renne, Sasson, Keren, Zozulya, Alla L., Smith, Paul, Schlapschy, Martin, Aharoni, Rina, Köster, Mario, Eilam, Raya, Skerra, Arne, Schreiber, Gideon
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200257/
https://ncbi.nlm.nih.gov/pubmed/25193661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602474
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items