Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis

IFNβ is a common therapeutic option to treat multiple sclerosis. It is unique among the family of type I IFNs in that it binds to the interferon receptors with high affinity, conferring exceptional biological properties. We have previously reported the generation of an interferon superagonist (dubbe...

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Hauptverfasser: Harari, Daniel, Kuhn, Nadine, Abramovich, Renne, Sasson, Keren, Zozulya, Alla L., Smith, Paul, Schlapschy, Martin, Aharoni, Rina, Köster, Mario, Eilam, Raya, Skerra, Arne, Schreiber, Gideon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200257/
https://ncbi.nlm.nih.gov/pubmed/25193661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602474
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