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Transforming Growth Factor β1 (TGF-β1) Enhances Expression of Profibrotic Genes through a Novel Signaling Cascade and MicroRNAs in Renal Mesangial Cells

Increased expression of transforming growth factor-β1 (TGF-β1) in glomerular mesangial cells (MC) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (DN), a debilitating renal complication of diabetes. MicroRNAs (miRNAs) play key roles in the pa...

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Detalhes bibliográficos
Main Authors: Castro, Nancy E., Kato, Mitsuo, Park, Jung Tak, Natarajan, Rama
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200256/
https://ncbi.nlm.nih.gov/pubmed/25204661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600783
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