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Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat

Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lower...

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Detaylı Bibliyografya
Asıl Yazarlar: Beverly, Brandiese E. J., Lambright, Christy S., Furr, Johnathan R., Sampson, Hunter, Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M. D., Travlos, Gregory, Gray, L. Earl
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
126
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200049/
https://ncbi.nlm.nih.gov/pubmed/25055962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu149
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