Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat

Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lower...

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Bibliografiska uppgifter
Huvudupphovsmän: Beverly, Brandiese E. J., Lambright, Christy S., Furr, Johnathan R., Sampson, Hunter, Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M. D., Travlos, Gregory, Gray, L. Earl
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Ämnen:
126
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200049/
https://ncbi.nlm.nih.gov/pubmed/25055962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu149
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