Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat

Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lower...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Beverly, Brandiese E. J., Lambright, Christy S., Furr, Johnathan R., Sampson, Hunter, Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M. D., Travlos, Gregory, Gray, L. Earl
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
126
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200049/
https://ncbi.nlm.nih.gov/pubmed/25055962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu149
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires