Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat

Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lower...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Beverly, Brandiese E. J., Lambright, Christy S., Furr, Johnathan R., Sampson, Hunter, Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M. D., Travlos, Gregory, Gray, L. Earl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
126
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200049/
https://ncbi.nlm.nih.gov/pubmed/25055962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu149
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge