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Simvastatin and Dipentyl Phthalate Lower Ex Vivo Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat

Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell differentiation, reducing the expression of several genes associated with steroid synthesis/transport, and consequently, lower...

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Bibliografiske detaljer
Main Authors: Beverly, Brandiese E. J., Lambright, Christy S., Furr, Johnathan R., Sampson, Hunter, Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M. D., Travlos, Gregory, Gray, L. Earl
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
126
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200049/
https://ncbi.nlm.nih.gov/pubmed/25055962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu149
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