Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli.

Holocarboxylase synthetase (HCS) catalyzes the biotinylation of the four biotin-dependent carboxylases in human cells. Patients with HCS deficiency lack activity of all four carboxylases, indicating that a single HCS is targeted to the mitochondria and cytoplasm. We isolated 21 human HCS cDNA clones...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	León-Del-Rio, A, Leclerc, D, Akerman, B, Wakamatsu, N, Gravel, R A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41997/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753853/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4626
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