Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP

The Arp2/3 complex can be independently activated to initiate actin polymerization by the VCA domain of WASP family members and by the acidic N-terminal and F-actin-binding repeat region of cortactin, which possesses a C-terminal SH3 domain. Cortactin is a target for phosphorylation by Src tyrosine...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Martinez-Quiles, Narcisa, Ho, Hsin-Yi Henry, Kirschner, Marc W., Ramesh, Narayanaswamy, Geha, Raif S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2004
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419870/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15169891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.12.5269-5280.2004
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