Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

Plasma high-density lipoprotein (HDL) levels show a strong inverse correlation with atherosclerotic vascular disease. Previous studies have demonstrated that antagonism of miR-33 in vivo increases circulating HDL and reverse cholesterol transport (RCT), thereby reducing the progression and enhancing...

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Autores principales: Goedeke, Leigh, Salerno, Alessandro, Ramírez, Cristina M, Guo, Liang, Allen, Ryan M, Yin, Xiaoke, Langley, Sarah R, Esau, Christine, Wanschel, Amarylis, Fisher, Edward A, Suárez, Yajaira, Baldán, Angel, Mayr, Manuel, Fernández-Hernando, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197861/
https://ncbi.nlm.nih.gov/pubmed/25038053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404046
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