A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor

Recently identified IDH mutations lead to the production of 2-hydroxyglutarate (2HG), an onco-metabolite aberrantly elevated in selected cancers. We developed a facile and inexpensive fluorimetric microplate assay for quantitation of 2HG and performed an unbiased small molecule screen in live cells...

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Bibliografiske detaljer
Main Authors: Elhammali, Adnan, Ippolito, Joseph E., Collins, Lynne, Crowley, Jan, Marasa, Jayne, Piwnica-Worms, David
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197823/
https://ncbi.nlm.nih.gov/pubmed/24740997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0572
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