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Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand

Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). Hh binding to Ptc is also proposed to sequester the ligand, limi...

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מידע ביבליוגרפי
Main Authors: Camp, Darius, Haitian He, Billy, Li, Sally, Althaus, Irene W., Holtz, Alexander M., Allen, Benjamin L., Charron, Frédéric, van Meyel, Donald J.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Company of Biologists 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197687/
https://ncbi.nlm.nih.gov/pubmed/25231763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.103564
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