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Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium

Collective migration of cells in the zebrafish posterior lateral line primordium (PLLp) along a path defined by Cxcl12a expression depends on Cxcr4b receptors in leading cells and on Cxcr7b in trailing cells. Cxcr7b-mediated degradation of Cxcl12a by trailing cells generates a local gradient of Cxcl...

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Detalhes bibliográficos
Main Authors: Dalle Nogare, Damian, Somers, Katherine, Rao, Swetha, Matsuda, Miho, Reichman-Fried, Michal, Raz, Erez, Chitnis, Ajay B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197546/
https://ncbi.nlm.nih.gov/pubmed/25063456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.106690
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