Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

BACKGROUND: Several single nucleotide polymorphisms (SNPs) at different loci have been associated with breast cancer susceptibility, accounting for around 10% of the familial component. Recent studies have found direct associations between specific SNPs and breast cancer in BRCA1/2 mutation carriers...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Prosperi, Mattia CF, Ingham, Sarah L, Howell, Anthony, Lalloo, Fiona, Buchan, Iain E, Evans, Dafydd Gareth
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197237/
https://ncbi.nlm.nih.gov/pubmed/25274085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6947-14-87
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